Differential expression of IL-33 and HMGB1 in the lungs of stable cystic fibrosis patients.
نویسندگان
چکیده
In cystic fibrosis (CF), repeated inflammation of the lung leads to progressive damage of lung tissue [1, 2]. In case of tissue destruction or in response to inflammation, necrotic cells release danger signals. These proteins trigger inflammatory responses, contribute to elimination of pathogens and induce tissue repair [3]. Imbalanced or uncontrolled release of such mediators may amplify inflammatory responses that in turn facilitate tissue damage.
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References 1 Tiringer K, Treis A, Fucik P, et al. A Th17and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for Pseudomonas aeruginosa infection. Am J Respir Crit Care Med 2013; 187: 621–629. 2 Liou TG, Adler FR, Keogh RH, et al. Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. PLoS One 2012; 7: e42748. 3 Hirsige...
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ورودعنوان ژورنال:
- The European respiratory journal
دوره 44 3 شماره
صفحات -
تاریخ انتشار 2014